exacerbation

英[ek,sæsə'beɪʃən] 美[ɪɡ,zæsə'beʃən]

1. action that makes a problem or a disease (or its symptoms) worse;

"the aggravation of her condition resulted from lack of care"

2. violent and bitter exasperation;

"his foolishness was followed by an exacerbation of their quarrel"